• Immunotherapy · Nov 2018

    Meta Analysis

    Risk of fatigue in cancer patients treated with anti programmed cell death-1/anti programmed cell death ligand-1 agents: a systematic review and meta-analysis.

    • Matteo Santoni, Alessandro Conti, Sebastiano Buti, Melissa Bersanelli, Laura Foghini, Francesco Piva, Matteo Giulietti, Lukas Lusuardi, and Nicola Battelli.
    • Oncology Unit, Macerata Hospital, via Santa Lucia 2, 62100, Macerata, Italy.
    • Immunotherapy. 2018 Nov 1; 10 (15): 1303-1313.

    AimWe aimed to assess the incidence and relative risk (RR) of fatigue in cancer patients treated with anti programmed cell death-1 (PD-1) and anti programmed cell death ligand-1 (PD-L1) agents.Patients & MethodsEligible studies were selected according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Incidence, RR and 95% CIs were calculated using random or fixed-effects models.ResultsThirty-eight studies were included in this analysis, with a total of 11,719 patients. The incidences were 23.4 and 2.1% for all- and high-grade fatigue, respectively. The highest incidence of high-grade fatigue was reported by the combination of nivolumab and ipilimumab. Overall RR of high-grade fatigue with anti-PD-1/PD-L1 compared with chemotherapy or targeted therapy was 0.48.ConclusionTreatment with anti-PD-1/PD-L1 agents correlates with lower incidence and RR of fatigue compared with standard therapies.

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