• Charat Thongprayoon, Wisit Kaewput, Natanong Thamcharoen, Tarun Bathini, Kanramon Watthanasuntorn, Sohail Abdul Salim, Patompong Ungprasert, Ploypin Lertjitbanjong, Narothama Reddy Aeddula, Aldo Torres-Ortiz, Michael A Mao, and Wisit Cheungpasitporn.
• Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA. charat.thongprayoon@gmail.com.
• J Clin Med. 2019 Jan 9; 8 (1).

BackgroundThe number of total hip arthroplasties (THA) performed across the world is growing rapidly. We performed this meta-analysis to evaluate the incidence of acute kidney injury (AKI) in patients undergoing THA.MethodsA literature search was performed using MEDLINE, EMBASE and Cochrane Database from inception until July 2018 to identify studies assessing the incidence of AKI (using standard AKI definitions of RIFLE, AKIN, and KDIGO classifications) in patients undergoing THA. We applied a random-effects model to estimate the incidence of AKI. The protocol for this meta-analysis is registered with PROSPERO (no. CRD42018101928).ResultsSeventeen cohort studies with a total of 24,158 patients undergoing THA were enrolled. Overall, the pooled estimated incidence rates of AKI and severe AKI requiring dialysis following THA were 6.3% (95% CI: 3.8%⁻10.2%) and 0.5% (95% CI: 0.1%⁻2.3%). Subgroup analysis based on the countries by continent was performed and demonstrated the pooled estimated incidence of AKI following THA of 9.2% (95% CI: 5.6%⁻14.8%) in Asia, 8.1% (95% CI: 4.9%⁻13.2%) in Australia, 7.4% (95% CI: 3.2%⁻16.3%) in Europe, and 2.8% (95% CI: 1.2%⁻17.0%) in North America. Meta-regression of all included studies showed significant negative correlation between incidence of AKI following THA and study year (slope = -0.37, p <0.001). There was no publication bias as assessed by the funnel plot and Egger's regression asymmetry test with p = 0.13 for the incidence of AKI in patients undergoing THA.ConclusionThe overall estimated incidence rates of AKI and severe AKI requiring dialysis in patients undergoing THA are 6.3% and 0.5%, respectively. There has been potential improvement in AKI incidence for patients undergoing THA over time.

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