• Eva Bueltmann, Gunter Erb, Miles A Kirchin, Uwe Klose, and Thomas Naegele.
• Department of Neuroradiology, University Hospital of Tübingen, Tübingen, Germany. Bueltmann.eva@mh-hannover.de
• Invest Radiol. 2008 Oct 1; 43 (10): 695-702.

ObjectiveTo compare gadobenate dimeglumine (Gd-BOPTA) and gadopentetate dimeglumine (Gd-DTPA) for contrast-enhanced magnetic resonance (MR) angiography of the supraaortic vessels at 3 Tesla.Materials And MethodsTwelve healthy volunteers each underwent two contrast-enhanced magnetic resonance angiography examinations, one with Gd-BOPTA and one with Gd-DTPA each at a dose of 0.1 mmol/kg bodyweight. The 2 examinations were performed in randomized order and were separated by at least 72 hours. Imaging was performed in the coronal plane at 3T (Magnetom TIM Trio Siemens) using a 12-channel neurovascular array coil. The MR sequence parameters were identical for all examinations. Maximum intensity projection reconstructions were evaluated separately and in matched-pairs by a single independent blinded reviewer in terms of qualitative (5-point scales for technical quality and vessel delineation) and quantitative (relative contrast-to-noise ratio) contrast enhancement across 19 arteries/arterial segments comprising the internal carotid arteries; anterior, middle, and posterior cerebral arteries; vertebral arteries; and basilar artery. Findings were compared using the Wilcoxon signed rank test.ResultsThe mean technical quality across all examinations was significantly (P = 0.031) greater after Gd-BOPTA. The overall median score for vessel delineation was also significantly higher for Gd-BOPTA than for Gd-DTPA (4.3 vs. 3.7; P = 0.005). Matched-pairs assessment revealed significant (P ConclusionSignificantly improved image quality and contrast enhancement is achieved at 3T with 0.1 mmol/kg Gd-BOPTA compared with 0.1 mmol/kg Gd-DTPA.

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