-
J Magn Reson Imaging · Jun 2018
Breast lesion characterization using whole-lesion histogram analysis with stretched-exponential diffusion model.
- Chunling Liu, Kun Wang, Xiaodan Li, Jine Zhang, Jie Ding, Karl Spuhler, Timothy Duong, Changhong Liang, and Chuan Huang.
- Department of Radiology, Guangdong General Hospital affiliated to South China University of Technology/Guangdong Academy of Medical Sciences, P.R. China.
- J Magn Reson Imaging. 2018 Jun 1; 47 (6): 1701-1710.
BackgroundDiffusion-weighted imaging (DWI) has been studied in breast imaging and can provide more information about diffusion, perfusion and other physiological interests than standard pulse sequences. The stretched-exponential model has previously been shown to be more reliable than conventional DWI techniques, but different diagnostic sensitivities were found from study to study.PurposeThis work investigated the characteristics of whole-lesion histogram parameters derived from the stretched-exponential diffusion model for benign and malignant breast lesions, compared them with conventional apparent diffusion coefficient (ADC), and further determined which histogram metrics can be best used to differentiate malignant from benign lesions.Study TypeThis was a prospective study.PopulationSeventy females were included in the study.Field Strength/SequenceMulti-b value DWI was performed on a 1.5T scanner.AssessmentHistogram parameters of whole lesions for distributed diffusion coefficient (DDC), heterogeneity index (α), and ADC were calculated by two radiologists and compared among benign lesions, ductal carcinoma in situ (DCIS), and invasive carcinoma confirmed by pathology.Statistical TestsNonparametric tests were performed for comparisons among invasive carcinoma, DCIS, and benign lesions. Comparisons of receiver operating characteristic (ROC) curves were performed to show the ability to discriminate malignant from benign lesions.ResultsThe majority of histogram parameters (mean/min/max, skewness/kurtosis, 10-90th percentile values) from DDC, α, and ADC were significantly different among invasive carcinoma, DCIS, and benign lesions. DDC10% (area under curve [AUC] = 0.931), ADC10% (AUC = 0.893), and αmean (AUC = 0.787) were found to be the best metrics in differentiating benign from malignant tumors among all histogram parameters derived from ADC and α, respectively. The combination of DDC10% and αmean , using logistic regression, yielded the highest sensitivity (90.2%) and specificity (95.5%).Data ConclusionDDC10% and αmean derived from the stretched-exponential model provides more information and better diagnostic performance in differentiating malignancy from benign lesions than ADC parameters derived from a monoexponential model.Level Of Evidence2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1701-1710.© 2017 International Society for Magnetic Resonance in Medicine.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.