• Feng Wang, Yuxiang Wang, Yan Zhou, Congrong Liu, Lizhi Xie, Zhenyu Zhou, Dong Liang, Yang Shen, Zhihang Yao, and Jianyu Liu.
• Department of Radiology, Peking University Third Hospital, Haidian District, Beijing, P.R. China.
• J Magn Reson Imaging. 2017 Dec 1; 46 (6): 1797-1809.

PurposeTo evaluate the utility of histogram analysis of monoexponential, biexponential, and stretched-exponential models to a dualistic model of epithelial ovarian cancer (EOC).Materials And MethodsFifty-two patients with histopathologically proven EOC underwent preoperative magnetic resonance imaging (MRI) (including diffusion-weighted imaging [DWI] with 11 b-values) using a 3.0T system and were divided into two groups: types I and II. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), distributed diffusion coefficient (DDC), and intravoxel water diffusion heterogeneity (α) histograms were obtained based on solid components of the entire tumor. The following metrics of each histogram were compared between two types: 1) mean; 2) median; 3) 10th percentile and 90th percentile. Conventional MRI morphological features were also recorded.ResultsSignificant morphological features for predicting EOC type were maximum diameter (P = 0.007), texture of lesion (P = 0.001), and peritoneal implants (P = 0.001). For ADC, D, f, DDC, and α, all metrics were significantly lower in type II than type I (P < 0.05). Mean, median, 10th, and 90th percentile of D* were not significantly different (P = 0.336, 0.154, 0.779, and 0.203, respectively). Most histogram metrics of ADC, D, and DDC had significantly higher area under the receiver operating characteristic curve values than those of f and α (P < 0.05) CONCLUSION: It is feasible to grade EOC by morphological features and three models with histogram analysis. ADC, D, and DDC have better performance than f and α; f and α may provide additional information.Level Of Evidence4 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2017;46:1797-1809.© 2017 International Society for Magnetic Resonance in Medicine.

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