• V M Pachón-Garrudo, J I Cuenca-Cuenca, J Ruiz-Franco-Baux, I Borrego-Dorado, J L Tirado-Hospital, E Navarro-González, and R Vázquez-Albertino.
• Unidad de Diagnóstico por la Imagen, Medicina Nuclear, Hospital Universitario Virgen del Rocío, Seville, Spain. victorpachon1@gmail.com
• Rev Esp Med Nucl Imagen Mol. 2012 Nov 1; 31 (6): 315-21.

ObjectiveThis study has aimed to analyze the evolution of patients diagnosed with differentiated thyroid carcinoma (DTC) with a negative (131)I-Na whole body scan (WBS), high levels of serum thyroglobulin (Tg) and negative (18F)fluorodeoxyglucose positron emission tomography (PET-FDG) study.Material And MethodsTwenty-three patients diagnosed and treated for DTC were studied retrospectively. Patients were aged between 23 and 83 and had shown, between January 2001 and December 2002, negative WBS, Tg values in a range of suspected recurrence or metastasis (Tg>2 ng / mL with thyroid hormone withdrawal) and a negative PET-FDG study. The patients were monitored clinically, radiologically and analytically for a minimum period of 4 years. After this, a new evaluation was made of their state of disease with a control WBS, also observing the evolution of Tg. All WBS were performed with a 185 MBq diagnostic dose of (131)I-Na.ResultsIn 18/23 patients, Tg decreased and in 5 it increased. Four patients (17%) were free of active disease (negative WBS Tg<2 ng / mL). A total of 16 patients (70%) were free of disease according to the WBS but had elevated Tg. Three patients (13%) had disease and high levels of Tg, two of them with positive WBS and the third with (99m)Tc-MIBI scan and CT positive.ConclusionsMost patients with a negative WBS, high Tg serum levels and negative FDG PET had good evolution, with descending Tg levels, normal levels even being reached in a significant percentage of them.Copyright © 2011 Elsevier España, S.L. y SEMNIM. All rights reserved.

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