• Biomed Res Int · Jan 2015

    Multicenter Study Clinical Trial

    Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer's Disease and Mild Cognitive Impairment: MRI and (18)F-FDG PET Quantitative Analysis Using FreeSurfer.

    • Matthieu Bailly, Christophe Destrieux, Caroline Hommet, Karl Mondon, Jean-Philippe Cottier, Emilie Beaufils, Emilie Vierron, Johnny Vercouillie, Méziane Ibazizene, Thierry Voisin, Pierre Payoux, Louisa Barré, Vincent Camus, Denis Guilloteau, and Maria-Joao Ribeiro.
    • Service de Médecine Nucléaire, CHRU de Tours, boulevard Tonnellé, 37000 Tours, France ; Service de Médecine Nucléaire, CHR Orléans, avenue de l'Hôpital, 45000 Orléans, France.
    • Biomed Res Int. 2015 Jan 1; 2015: 583931.

    ObjectiveThe objective of this study was to compare glucose metabolism and atrophy, in the precuneus and cingulate cortex, in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), using FreeSurfer.Methods47 individuals (17 patients with AD, 17 patients with amnestic MCI, and 13 healthy controls (HC)) were included. MRI and PET images using (18)F-FDG (mean injected dose of 185 MBq) were acquired and analyzed using FreeSurfer to define regions of interest in the hippocampus, amygdala, precuneus, and anterior and posterior cingulate cortex. Regional volumes were generated. PET images were registered to the T1-weighted MRI images and regional uptake normalized by cerebellum uptake (SUVr) was measured.ResultsMean posterior cingulate volume was reduced in MCI and AD. SUVr were different between the three groups: mean precuneus SUVr was 1.02 for AD, 1.09 for MCI, and 1.26 for controls (p < 0.05); mean posterior cingulate SUVr was 0.96, 1.06, and 1.22 for AD, MCI, and controls, respectively (p < 0.05).ConclusionWe found graduated hypometabolism in the posterior cingulate cortex and the precuneus in prodromal AD (MCI) and AD, whereas atrophy was not significant. This suggests that the use of (18)F-FDG in these two regions could be a neurodegenerative biomarker.

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