• Semin Nucl Med · Apr 2002

    Review

    Somatostatin receptor imaging of non-small cell lung cancer with 99mTc depreotide.

    • Yusuf Menda and Daniel Kahn.
    • Division of Nuclear Medicine, University of Iowa College of Medicine, Iowa City, IA 52246, USA.
    • Semin Nucl Med. 2002 Apr 1; 32 (2): 92-6.

    AbstractSeveral tumors overexpress somatostatin receptors (SSTR) and can thus be imaged with radiolabeled analogues of somatostatin. Tc-99m depreotide is a new radiolabeled somatostatin analogue that shows high affinity for SSTR2, SSTR3, and SSTR5 subtypes. It has been recently FDA-approved for use in the evaluation of indeterminate solitary pulmonary nodules. SPECT with Tc-99m depreotide is highly accurate in this clinical setting and may be preferable to FDG-PET because of its lower cost and wider availability. Large studies are also underway to evaluate the accuracy of Tc-99m depreotide in staging of lung cancer.Copyright 2002, Elsevier Science.

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