• Neuroreport · Apr 2005

    Review

    Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis.

    • Patrick Weydt and Thomas Möller.
    • Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98195-6465, USA.
    • Neuroreport. 2005 Apr 25; 16 (6): 527-31.

    AbstractAmyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and its animal models. A better understanding of neuroinflammation in motor neuron degeneration and amyotrophic lateral sclerosis disease progression promises to improve the rational design of greatly needed therapies.

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