• Hong Li, Hang Sun, Siqi Liu, Wei Zhang, Felicity Mmaezi Arukalam, He Ma, and Wei Qian.
• Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, China.
• J Magn Reson Imaging. 2019 Aug 1; 50 (2): 465-473.

BackgroundDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is increasingly being used to detect and diagnose breast cancer. However, the effective methods based on quantitative feature analysis need to be explored.PurposeTo investigate a new approach for improving the performance of benign and malignant breast lesion classification by combining bilateral time-intensity curve (TIC) differentiation features with other effective features.Study TypeRetrospective.PopulationIn all, 112 DCE-MRI biopsy-proven breast examinations (45 malignant tumors and 67 benign tumors).Field Strength/Sequence3 T MR with a breast coil. Precontrast images were acquired before contrast administration. Subsequently, postcontrast images were acquired approximately every minute directly following administration of the contrast agent (gadopentetate dimeglumine). The postcontrast images contain eight sequences in total. Each sequence contains 78 slices.AssessmentAccuracy, sensitivity, specificity, and the area under the curve (AUC) of the classification was calculated and compared with the published result.Statistical TestsFive-fold crossvalidation was used.ResultsAreas under the receiver operating characteristic (ROC) curve (AUCs) of 0.8461, 0.7914, 0.8514, and 0.9058 were achieved using conventional features, unilateral TIC features, bilateral TIC differentiation features, and all the selected features, respectively. In terms of accuracy, the use of only unilateral TIC features or conventional features achieved an accuracy of 0.7321 or 0.8482 (sensitivity of 0.7556 or 0.7111 and specificity of 0.7164 or 0.9403). However, the accuracy increased to 0.9196 (sensitivity of 0.8889 and specificity of 0.9403) when bilateral TIC differentiation features were included.Data ConclusionBilateral differentiation TIC features can serve as a stronger indicator in differentiating benign and malignant breast lesions than the unilateral TIC features computed from one side of the breast only and some conventional features that are commonly used in MR image analysis.Level Of Evidence1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:465-473.© 2019 International Society for Magnetic Resonance in Medicine.

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