• Benjian Chen, Yuanping Wang, Zhuogen He, Dawei Wang, Xia Yan, and Pingchang Xie.
• The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
• Medicine (Baltimore). 2018 Feb 1; 97 (8): e9972e9972.

BackgroundEssential hypertension is one of the most common chronic diseases, as well as one of the leading risk factors for cardio-cerebrovascular diseases. Tianma Gouteng decoction has been commonly used in clinical practice for patients with essential hypertension. It is important to update the search and evaluation to provide the best available evidence for essential hypertension. Here, we provide a protocol to evaluate the efficacy and safety of Tianma Gouteng decoction (TGD) for essential hypertension.MethodsRetrieve literature on the TGD treatment for essential hypertension in the databases including PubMed, Cochrane Library, EMBASE, Chinese Biomedical database (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang database, and Chinese Science and Technology Periodical database (VIP) on computer. The literature to be collected will be those published from the time when the respective databases were established to January 2018. The therapeutic effects according to the blood pressure (BP) will be accepted as the primary outcomes. We will use RevMan V.5.3 software as well to compute the data synthesis carefully when a meta-analysis is allowed.ResultsThis study will provide a high-quality synthesis of current evidence of TGD for essential hypertension from several aspects including BP, life quality, heart rate, and adverse events.ConclusionThe conclusion of our systematic review will provide evidence to judge whether TGD is an effective intervention for patient with essential hypertension.Prospero Registration NumberPROSPERO CRD 42018082319.

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