• Ponnada A Narayana, Ivan Coronado, Sheeba J Sujit, Jerry S Wolinsky, Fred D Lublin, and Refaat E Gabr.
• Department of Diagnostic and Interventional Imaging, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
• J Magn Reson Imaging. 2020 May 1; 51 (5): 1487-1496.

BackgroundThe dependence of deep-learning (DL)-based segmentation accuracy of brain MRI on the training size is not known.PurposeTo determine the required training size for a desired accuracy in brain MRI segmentation in multiple sclerosis (MS) using DL.Study TypeRetrospective analysis of MRI data acquired as part of a multicenter clinical trial.Study PopulationIn all, 1008 patients with clinically definite MS.Field Strength/SequenceMRIs were acquired at 1.5T and 3T scanners manufactured by GE, Philips, and Siemens with dual turbo spin echo, FLAIR, and T1 -weighted turbo spin echo sequences.AssessmentSegmentation results using an automated analysis pipeline and validated by two neuroimaging experts served as the ground truth. A DL model, based on a fully convolutional neural network, was trained separately using 16 different training sizes. The segmentation accuracy as a function of the training size was determined. These data were fitted to the learning curve for estimating the required training size for desired accuracy.Statistical TestsThe performance of the network was evaluated by calculating the Dice similarity coefficient (DSC), and lesion true-positive and false-positive rates.ResultsThe DSC for lesions showed much stronger dependency on the sample size than gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF). When the training size was increased from 10 to 800 the DSC values varied from 0.00 to 0.86 ± 0.016 for T2 lesions, 0.87 ± 009 to 0.94 ± 0.004 for GM, 0.86 ± 0.08 to 0.94 ± 0.005 for WM, and 0.91 ± 0.009 to 0.96 ± 0.003 for CSF.Data ConclusionExcellent segmentation was achieved with a training size as small as 10 image volumes for GM, WM, and CSF. In contrast, a training size of at least 50 image volumes was necessary for adequate lesion segmentation.Level Of Evidence1 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2020;51:1487-1496.© 2019 International Society for Magnetic Resonance in Medicine.

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