• Man-Yu Zhang, Tong Li, Xiao-Yan Qian, Hui Liu, Qian-Nan Zhao, Cai-Cai Liu, Yong Wang, John P Williams, and Jian-Xiong An.
• School of Anesthesiology, Weifang Medical University, Weifang City, Shandong Province, China; Department of Anesthesiology, Pain and Sleep Medicine, Aviation General Hospital of China Medical University and Beijing Institute of Translational Medicine, Chinese Academy of Sciences, Beijing, China.
• Pain Physician. 2021 May 1; 24 (3): E367-E375.

BackgroundNumerous therapies have been developed for the treatment of chronic pelvic pain (CPP). Oxygen-ozone therapy is a new method for the treatment of CPP.ObjectivesThis article evaluated the feasibility of ultrasound-guided peritoneal perfusion with ozone in patients with CPP.Study DesignThis is a bicenter retrospective study.SettingThe study was conducted at 2 pain centers of a university hospital.MethodsThe medical records of patients with CPP (n = 60) from March 2016 until October 2018 were collected and reviewed. Group A contained 19 patients who were treated with a 1500 mcg dose of ozonated water (10 mcg/mL concentration and 150 mL volume), group B contained 23 patients using the same dose of ozonated water but a 15 mcg/mL concentration and 100 mL volume. Group C included 18 patients using a similar ozone dose but delivered in an oxygen-ozone mixture (15 mcg/mL concentration and 100 mL volume oxygen-ozone mixture). Visual Analog Scale (VAS) scores for pain of the 3 groups were compared at pretreatment, posttreatment, 1, 3, and 6 months posttreatment. The injection pain was evaluated using a 4-point verbal rating scale. Quality of life (QoL), anxiety, and depression were assessed at pretreatment and at 6 months posttreatment.ResultsThe VAS scores of the 3 groups decreased over time following treatment. Group A showed much higher pain scores compared with groups B and C at 1, 3, and 6 months posttreatment. However, the injection pain for groups B and C was higher than group A, but there was no difference seen between group B and C. At 6 months posttreatment, the QoL for all patients improved compared with pretreatment, whereas the anxiety and depression did not demonstrate differences.LimitationsThe main limitations of this study are the retrospective study design, limited case number, and short follow-up period.ConclusionsUltrasound-guided peritoneal perfusion with ozone is a feasible therapy for patients with CPP.

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