• Human reproduction · Aug 1994

    Case Reports

    Ovarian cyst formation in two pre-menopausal patients treated with tamoxifen for breast cancer.

    • A Shulman, I Cohen, M M Altaras, R Maymon, I Ben-Nun, R Tepper, and Y Beyth.
    • Department of Obstetrics and Gynaecology, Sapir Medical Centre, Kfar Saba, Israel.
    • Hum. Reprod. 1994 Aug 1; 9 (8): 1427-9.

    AbstractPre-menopausal tamoxifen treatment causes hyperoestrogen production and ovarian cyst formation. Two pre-menopausal breast cancer patients who were treated with tamoxifen developed both permanent supraphysiological oestrogen concentration and ovarian cysts. Serum oestrogen decreased to post-menopausal concentrations and ovarian cysts completely resolved during and following simultaneous treatment with tamoxifen and gonadotrophin-releasing hormone agonist (GnRHa). In pre-menopausal breast cancer patients, GnRHa may prevent possible side-effects of tamoxifen, such as ovarian cysts and supraphysiological oestrogen production.

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