• Pierpaolo Mincarone, Antonella Bodini, Saverio Sabina, Riccardo Colella, Maria Rosaria Tumolo, Martin Fawdry, Dimitrios I Fotiadis, and Carlo Giacomo Leo.
• National Research Council, Institute for Research on Population and Social Policies, Research Unit of Brindisi, Brindisi.
• Medicine (Baltimore). 2021 Jun 25; 100 (25): e26198e26198.

BackgroundIn silico medicine allows for pre-clinical and clinical simulated assessment of medical technologies and the building of patient-specific models to support medical decisions and forecast personal health status. While there is increasing trust in the potential central role of in silico medicine, there is a need to recognize its degree of reliability and evaluate its economic impact. An in silico platform has been developed within a Horizon 2020-funded project (In-Silc) for simulations functional to designing, developing, and assessing drug-eluting bioresorbable vascular scaffolds.The main purpose of this study was to compare the costs of 2 alternative strategies: the adoption of In-Silc platform versus the performance of only physical bench tests.MethodsA case study was provided by a medical device company. The values of the model parameters were principally set by the project partners, with use of interviews and semi-structured questionnaires, and, when not available, through literature searches or derived by statistical techniques. An economic model was built to represent the 2 scenarios.ResultsThe InSilc strategy is superior to the adoption of physical bench tests only. Ceteris paribus, the costs are 424,355€ for the former versus 857,811€ for the latter.ConclusionsIn silico medicine tools can decrease the cost of the research and development of medical devices such as bioresorbable vascular scaffolds. Further studies are needed to explore the impact of such solutions on the innovation capacity of companies and the consequent potential advantages for target patients and the healthcare system.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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