• Haoran Wang, Xiaoyan Fu, Jing Ju, Dan Meng, Shengming Sun, Chenchen Guo, Hongling Jia, and Qiangsan Sun.
• Department of Rehabilitation Medicine, The Second Hospital of Shandong University.
• Medicine (Baltimore). 2021 Jun 25; 100 (25): e26413e26413.

BackgroundLacunar infarction (LI) is the mild type in the classification of ischemic stroke, mostly occurs in the middle-aged and elderly, with mild hemiplegia and partial sensory disorder as the main manifestations. In the treatment of LI, acupuncture is often regarded as dominant therapy in the convalescence period. However, acupuncture for treatment of LI in the recovery period lacks high-quality reports and evidence-based medical evidence. Thus, we aim to evaluate the curative effect and safety of acupuncture for LI objectively.MethodsPubmed, Cochrane Library, Web of Science, EBSCO, Springer, China National Knowledge Infrastructure, Chinese Scientific and Technical Journals Database (VIP), Wan-fang Database, Chinese Biomedical Literature Database, Chinese Science Citation Database, and other electronic databases will be retrieved from the inception to May, 2021. Randomized controlled trials related to this subject will be searched. The inclusion criteria are established and a detailed literature search strategy is designed through discussion. Article retrieval, screening, excluding repetitive studies, assessment of quality, and data processing will be conducted by 2 reviewers independently using EndNote (X9) and Review Manager (5.3.5). The outcome measures include primary outcome measures (total effective rate, National Institute of Health Stroke Scale score, and Fugl-Meyer Assessment score), secondary outcome measures (blood pressure, plasma glucose, and blood lipid), and safety outcome measures. We will perform a meta-analysis, descriptive analysis, and subgroup analysis based on data conditions.ResultsThe study of total effective rate, National Institute of Health Stroke Scale score, Fugl-Meyer Assessment score, blood pressure, plasma glucose, blood lipid, and adverse effects will provide evidenced outcome for high-quality synthesis and descriptive analysis.ConclusionThis systematic review will kindly provide evidence of whether acupuncture is an effective and safe intervention for LI in the recovery period.Inplasy Registration NumberINPLASY202150060 (DOI:10.37766/inplasy2021.5.0060).Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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