• Li-Yan Ni and Ji-You Tang.
• Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University.
• Medicine (Baltimore). 2021 Jun 25; 100 (25): e26453e26453.

BackgroundRecent observations raised concern that the intravenous recombinant tissue plasminogen activator (rt-PA) may result in damage to stroke patients caused by small artery occlusion (SAO). Thus, we perform a protocol for meta-analysis to investigate the efficacy and safety of intravenous thrombolysis with rt-PA in SAO-patients.MethodsThe search-style electronic libraries, including Pubmed, Embase, the Cochrane Library, Web of Science, Wanfang Data, VIP Chinese Journals, and China Biomedical Literature Service System are used for document retrieval in June 2021 with no restrictions on language. The risk of bias in include articles will be assessed using the Cochrane Risk of Bias Tool. We perform the meta-analysis by Stata version 10.0 software and calculated the statistics using the inverse variance statistical method. Binary outcomes are presented as Mantel-Haenszel-style risk ratios with 95% confidence interval. Continuous outcomes are reported as mean differences.ResultsThe results of the article will be shown in a peer-reviewed journal.ConclusionIntravenous rt-PA may be effective and safe in SAO-patients.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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