• Tingting Du, Wangyan Jiang, Hongchang Luo, Fuqiong Chen, Gang Yuan, Muxun Zhang, and Zhelong Liu.
• Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Branch of National Clinical Research Center for Metabolic Disease, Hubei.
• Medicine (Baltimore). 2021 Jun 25; 100 (25): e26469e26469.

RationaleWith the absence of ophthalmopathy, thyroid dermopathy especially lesions at atypical locations is a very rare presentation. We herein report an original case of bilateral breast myxedema caused by Grave's disease.Patient ConcernsA 21-year-old unmarried woman presented with a 4-month history of Grave's disease and a 1-month history of progressive bilateral breast enlargement. She had symmetrical bilateral breast enlargement with redness and nonpitting thickening of the skin, diffusely enlarged thyroid glands, and no exophthalmos.DiagnosisUltrasonography, magnetic resonance imaging scan, and skin biopsy confirmed the diagnosis of bilateral breast myxedema.InterventionsThe patient was treated with multipoint subcutaneous injections of triamcinolone acetonide in each breast every month.OutcomesThe bilateral breast returned approximately to its normal size after therapy for 6 months.ConclusionsOur case illustrates that multipoint subcutaneous injection of glucocorticoids is beneficial for bilateral breast myxedema.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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