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Expert review of vaccines · May 2015
ReviewPolio endgame: the global introduction of inactivated polio vaccine.
- Manish Patel, Simona Zipursky, Walt Orenstein, Julie Garon, and Michel Zaffran.
- Task Force for Global Health, 325 Swanton Way, Atlanta, GA 30330, USA.
- Expert Rev Vaccines. 2015 May 1; 14 (5): 749-62.
AbstractIn 2013, the World Health Assembly endorsed a plan that calls for the ultimate withdrawal of oral polio vaccines (OPV) from all immunization programs globally. The withdrawal would begin in a phased manner with removal of the type 2 component of OPV in 2016 through a global switch from trivalent OPV to bivalent OPV (containing only types 1 and 3). To mitigate risks associated with immunity gaps after OPV type 2 withdrawal, the WHO Strategic Advisory Group of Experts has recommended that all 126 OPV-only using countries introduce at least one dose of inactivated polio vaccine into routine immunization programs by end-2015, before the trivalent OPV-bivalent OPV switch. The introduction of inactivated polio vaccine would reduce risks of reintroduction of type 2 poliovirus by providing some level of seroprotection, facilitating interruption of transmission if outbreaks occur, and accelerating eradication by boosting immunity to types 1 and 3 polioviruses.
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