• Heart Rhythm · Jun 2015

    Multicenter Study

    Clinical safety of the ProMRI pacemaker system in patients subjected to head and lower lumbar 1.5-T magnetic resonance imaging scanning conditions.

    • William M Bailey, Lawrence Rosenthal, Lameh Fananapazir, Marye Gleva, Alexander Mazur, C A Rinaldi, Alexander Kypta, Béla Merkely, Pamela K Woodard, and ProMRI/ProMRI AFFIRM Study Investigators.
    • Louisiana Heart Rhythm Specialists and Lafayette General Medical Center, Lafayette, Louisiana. Electronic address: wbailey@heartrhythmmd.com.
    • Heart Rhythm. 2015 Jun 1; 12 (6): 1183-91.

    BackgroundPermanent cardiac pacemakers have historically been considered a contraindication to magnetic resonance imaging (MRI).ObjectiveThe purpose of the ProMRI/ProMRI AFFIRM Study, which was a multicenter, prospective, single-arm, nonrandomized study, was to evaluate the clinical safety of the Biotronik ProMRI Pacemaker System under specific MRI conditions.MethodsThe ProMRI Study (in the United States) and the ProMRI AFFIRM study (outside the United States) with identical design enrolled 272 patients with stable baseline pacing indices implanted with an Entovis or Evia pacemaker (DR-T or SR-T) and Setrox or Safio 53-cm or 60-cm lead. Device interrogation was performed at enrollment, pre-MRI and post-MRI scan, and 1 and 3 months post-MRI. End-points were (1) freedom from MRI- and pacing system-related serious adverse device effects (SADEs) through 1 month post-MRI, (2) freedom from atrial and ventricular MRI-induced pacing threshold increase (>0.5 V), and (3) freedom from P- and R-wave amplitude attenuation (<50%), or P wave <1.5 mV, or R wave <5.0 mV at 1 month post-MRI.ResultsTwo hundred twenty-six patients completed the MRI and 1-month post-MRI follow-up. No adverse events related to the implanted system and the MRI procedure occurred, resulting in an SADE-free rate of 100.0% (229/229, P <.001). Freedom from atrial and ventricular pacing threshold increase was 99.0% (189/191, P = .003) and 100% (217/217, P <.001), respectively. Freedom from P- and R- wave amplitude attenuation was 99.4% (167/168, P <.001) and 99.5% (193/194, P <.001), respectively.ConclusionThe results of the ProMRI/ProMRI AFFIRM studies demonstrate the clinical safety and efficacy of the ProMRI pacemaker system in patients subjected to head and lower lumbar MRI conditions.Copyright © 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

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