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- Naoya Harada, Hiroyuki Kimura, Satoru Onoe, Hiroyuki Watanabe, Daiko Matsuoka, Kenji Arimitsu, Masahiro Ono, and Hideo Saji.
- Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto University, Kyoto, Japan.
- J. Nucl. Med. 2016 Dec 1; 57 (12): 1978-1984.
AbstractProstate-specific membrane antigen (PSMA) is a membrane protein highly expressed on prostate cancer cells and a potential imaging target for diagnosis. 18F-DCFPyL has been recently developed as an effective probe with high diagnostic accuracy for prostate cancer imaging. However, its radiochemical yield is low. We developed new PSMA probes using succinimidyl 4-18F-fluorobenzoate (18F-SFB), a rapid and effective 18F-labeling agent, taking advantage of the high radiochemical yield of this compound. We evaluated the probes as PET probes for PSMA imaging.© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
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