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Review Meta Analysis
Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis.
- Wei Huang, Julie Berube, Michelle McNamara, Suraj Saksena, Marsha Hartman, Tariq Arshad, Scott J Bornheimer, and Maurice O'Gorman.
- BD Biosciences, San Jose, California, USA.
- Cytometry A. 2020 Aug 1; 97 (8): 772-776.
AbstractA reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized coronavirus disease 2019 (COVID-19) patients. In this brief meta-analysis, the reduction of lymphocyte subset counts in COVID-19 patients was investigated across 20 peer-reviewed studies meeting criteria for reporting lymphocyte subset counts and COVID-19 disease severity. CD4+ T cell, CD8+ T cell, B cell, NK cell, and total lymphocyte cell counts all showed statistically significant reduction in patients with severe/critical COVID-19 disease compared to mild/moderate disease. T-cell subsets showed the largest standardized magnitude of change. In some studies, multivariate analysis has shown that CD4 and/or CD8 T-cells counts are independently predictive of patient outcomes. © 2020 International Society for Advancement of Cytometry.© 2020 International Society for Advancement of Cytometry.
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