• Best Pract Res Clin Haematol · Jun 2018

    Review

    CAR T cell therapy for B-cell lymphomas.

    • Julio C Chavez and Frederick L Locke.
    • Department of Malignant Hematology, Moffitt Cancer Center, Tampa, USA.
    • Best Pract Res Clin Haematol. 2018 Jun 1; 31 (2): 135-146.

    AbstractB-cell non-Hodgkin's lymphoma (NHLs)is a very heterogonous malignancy with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) as the most common subtypes. Standard treatment with anti-CD20 based chemoimmunotherapy is usually very effective for disease control. However a significant proportion of patients with high-risk features (double hit lymphoma, transformed lymphomas or early relapses) will become refractory to standard therapies and will have limited alternatives for cure. Adoptive therapy with chimeric antigen receptor (CAR) T-cells is a new paradigm for effective treatment of poor prognosis lymphomas. Here we review the biology of poor risk DLBCL and FL, the rationale for CAR T-cell therapy in malignant lymphoma and the efficacy/toxicity profile of CD19 directed CAR T cell therapy for DLBCL and FL from early single center studies to multicenter/global clinical trial with different CAR T cell constructs.Copyright © 2018. Published by Elsevier Ltd.

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