• Helda Tutunchi, Majid Mobasseri, Naser Aghamohammadzadeh, Jalil Hooshyar, Fatemeh Naeini, and Farzad Najafipour.
• Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
• Int. J. Clin. Pract. 2021 Oct 1; 75 (10): e14555.

ObjectiveThe current case-control study aimed to examine the association of circulating neuregulin 4 (NRG-4), a brown fat-enriched endocrine factor, with non-alcoholic fatty liver disease (NAFLD).MethodsA total of 50 patients newly diagnosed with NAFLD with 50 age-matched and sex-matched subjects without NAFLD were recruited in the present study. Circulating NRG-4 levels were assessed with an enzyme-linked immunosorbent assay (ELISA) kit. SPSS version 23 was used for statistical analysis.ResultsPatients with NAFLD had lower levels of circulating NRG-4 than the control group (P < .001). Participants in the highest quartile of circulating NRG-4 had significantly lower body mass index (BMI), waist circumference (WC), triglyceride (TG) and homeostatic model assessment for insulin resistance (HOMA-IR) compared with those in the lowest quartile (all P < .01). The prevalence of NAFLD in the quartile 4 of the serum NRG-4 level was 38.46%, lower than the quartile 1 (62.50%, P = .006), quartile 2 (52.00%, P = .017) and quartile 3 (48.00%, P = .032). In multiple stepwise regression analysis, BMI (β = -0.712, P = .016), WC (β = -0.577, P = .023), TG (β = -0.509, P = .001), high-density lipoprotein cholesterol (HDL-C) (β = 0.489, P = .001) and HOMA-IR (β = -0.609, P = .003) were independently related to serum NRG-4 level. The odds of NAFLD decreased by 41% per 1 SD increase in serum NRG-4 level (OR, 0.59; 95% CI, 0.35-0.78; P = .021), after adjustment for all potential confounders.ConclusionThe results of the present study demonstrate that circulating NRG-4 levels may play a protective role in NAFLD.© 2021 John Wiley & Sons Ltd.

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