• Tomoyuki Noguchi, Masatou Kawashima, Hiroyuki Irie, Takateru Ootsuka, Masashi Nishihara, Toshio Matsushima, and Sho Kudo.
• Department of Radiology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan. tnogucci@radiol.med.kyushu-u.ac.jp
• Eur J Radiol. 2011 Dec 1; 80 (3): e557-62.

ObjectiveArterial spin-labeling (ASL) is a noninvasive magnetic resonance (MR) imaging method used to obtain brain perfusion information on various cerebrovascular diseases. We retrospectively compared the use of ASL-MRI and single-photon emission CT (SPECT) imaging to determine absolute cerebral blood flow (CBF) in moyamoya disease.Materials And MethodsCBF examinations using ASL-MRI on 3-T MRI and SPECT imagings with iodine-123-N-isopropyl-p-iodoamphetamine at resting (rest-IMP) and after acetazolamide challenge (ACZ-IMP) were performed on 12 patients with moyamoya disease (men, 5; women, 7; age range/average (year), 7-66/35.0). The CBF values determined by ASL-MRI (ASL-value), rest-IMP (rest-IMP-value), and ACZ-IMP (ACZ-IMP-value) of cerebral hemispheres (24 sides) were measured with normalized CBF maps created from data of those 3 perfusion imaging methods. Cerebrovascular reactivity (CVR) was calculated as follows: {(ACZ-IMP-value)-(rest-IMP-value)}/(rest-IMP-value)×100 (%). The ASL-value was compared with the rest-IMP-value, ACZ-IMP-value, and CVR.ResultsThe ASL-value, rest-IMP-value, ACZ-IMP-value, and CVR (average±standard deviation) were 26.6±14.8 (mL/100 g/min), 27.5±6.4 (mL/100 g/min), 37.1±13.2 (mL/100 g/min), and 35.9±44.3 (%), respectively. Significant relationships between the ASL-value versus (vs.) the rest-IMP-value (rs=0.500, p<0.05), the ASL-value vs. the ACZ-IMP-value (rs=0.863, p<0.01), and the ASL-value vs. the CVR (rs=0.699, p<0.01) were observed.ConclusionAlthough the ASL-value was lower than the rest-IMP-value, the significant relationship between the ASL-value and the rest-IMP-value may suggest that perfusion imaging by ASL-MRI could be used to recognize the condition of brain perfusion. In particular, the stronger correlation coefficient between the ASL-value and ACZ-IMP-value might suggest that perfusion imaging by ASL-MRI could show the potentially dangerous zone for ischemia.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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