• Br. J. Haematol. · Aug 2017

    Multicenter Study Clinical Trial

    Prognostic models for primary mediastinal (thymic) B-cell lymphoma derived from 18-FDG PET/CT quantitative parameters in the International Extranodal Lymphoma Study Group (IELSG) 26 study.

    • Luca Ceriani, Maurizio Martelli, Annarita Conconi, Pier L Zinzani, Ferreri Andrés J M AJM Department of Oncology, Unit of Lymphoid Malignancies, San Raffaele Hospital, Milan, Italy., Barbara Botto, Caterina Stelitano, Manuel Gotti, Maria G Cabras, Luigi Rigacci, Luca Giovanella, Emanuele Zucca, and Peter W M Johnson.
    • Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland.
    • Br. J. Haematol. 2017 Aug 1; 178 (4): 588-591.

    AbstractThe International Extranodal Lymphoma Study Group-26 study evaluated the prognostic role of 18-fluorodeoxyglucose positron-emission tomography (PET) in primary mediastinal large B-cell lymphoma. We assessed quantitative PET parameters at diagnosis and post-treatment in 100 patients. The end-of-therapy total lesion glycolysis (TLG) was the best individual outcome predictor, but the combination of baseline TLG and end-of-therapy visual analysis with Deauville Score (DS) showed a better positive predictive value. A model in which baseline TLG is combined with interim DS might identify patients with shorter progression-free survival. PET metrics combined with interim DS may allow early risk assessment and warrants further studies.© 2017 John Wiley & Sons Ltd.

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