• Acta haematologica · Jan 2012

    Case Reports

    Combining nilotinib and imatinib improves the outcome of imatinib-resistant blast phase CML.

    • Guang-Rong Zhu, Ou Ji, Jian-Min Ji, Ya-Cheng Zhang, Yu Wu, Hui Yu, Peng-Jun Jiang, and Qun Shen.
    • Department of Hematology, First Affiliated Hospital of Nanjing University of Chinese Medicine, China.
    • Acta Haematol. 2012 Jan 1; 127 (3): 152-5.

    AbstractImatinib resistance is an important hurdle in the treatment of chronic myeloid leukemia (CML), and CML patients with this drug resistance are often given a dismal prognosis. In this case report, an imatinib-refractory blast phase CML patient was treated with a combination of imatinib and nilotinib. A complete hematologic response was achieved within 3 months, the drug combination was well tolerated, and there was a relatively long bone-marrow complete remission. These results suggest that combining imatinib and nilotinib treatment may improve the outcome of imatinib-resistant CML patients in the blast phase. We hypothesize regarding the possible mechanism for the effectiveness of the drug combination by reviewing the recent literature.Copyright © 2012 S. Karger AG, Basel.

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