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Expert Rev Anticancer Ther · Jan 2016
ReviewNivolumab for the treatment of classical Hodgkin lymphoma after failure of autologous stem cell transplant and brentuximab.
- Jose C Villasboas and Stephen M Ansell.
- a Department of Medicine/Division of Hematology , Mayo Clinic , Rochester , MN , USA.
- Expert Rev Anticancer Ther. 2016 Jan 1; 16 (1): 5-12.
AbstractCancer cells are able to escape surveillance from the immune system by co-opting physiologic mechanisms such as the programmed cell death-1 (PD-1) receptor pathway. Agents able to block the interaction between the PD-1 receptor and its ligands have the potential to release T cells from tumor-induced suppression and eradicate malignant cells. Nivolumab - a PD-1 inhibitor - is approved for the treatment of patients with metastatic melanoma and lung cancer. This agent has been tested in patients with advanced Hodgkin lymphoma (HL) and showed impressive results in a phase I trial. Here we review the profile of Nivolumab including its pharmacological properties, clinical efficacy and safety in patients with advanced classical HL.
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