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Case Reports
Complete response of multiple melanoma brain metastases after treatment with temozolomide.
- J Dvorak, B Melichar, J Zizka, D Hadzi-Nikolov, and J Petera.
- Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic. dvorakj@fnhk.cz
- Onkologie. 2004 Apr 1; 27 (2): 171-4.
BackgroundInoperable melanoma brain metastases are usually uniformly fatal, and complete response after cytotoxic therapy is rare.Case ReportA patient with multiple inoperable melanoma brain metastases was treated with 6 cycles of oral temozolomide (300 mg once daily over 5 days every 28 days). A complete response was documented by magnetic resonance.ConclusionsThe present observation suggests that temozolomide may be an active and well tolerated treatment for malignant melanoma brain metastases.Copyright 2004 S. Karger GmbH, Freiburg
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