• Chang Liu, Yingjian Zhang, Yongping Zhang, Mingwei Wang, Rui Liu, Xiaohang Liu, and Silong Hu.
• Departments of aNuclear Medicine bDiagnostic Radiology, Fudan University Shanghai Cancer Center cDepartment of Oncology, Shanghai Medical College dCenter for Biomedical Imaging, Fudan University eShanghai Engineering Research Center for Molecular Imaging Probes, Shanghai, People's Republic of China.
• Nucl Med Commun. 2016 May 1; 37 (5): 446-52.

ObjectiveTo evaluate the use of fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) in the diagnosis of cutaneous extranodal natural killer/T-cell lymphoma, nasal type (C-ENK/T-NT).MethodsA total of 39 patients with newly diagnosed C-ENK/T-NT were enrolled between May 2006 and November 2013. Anatomic regions (n=429; five cutaneous and six extracutaneous regions per patient) were assessed using an F-FDG PET/CT scan and conventional staging methods (CSMs). F-FDG PET/CT and CSMs were compared and evaluated for their ability to detect tumor lesions and their influence on the staging and treatment strategies. Biopsy and clinical follow-up were used as the gold standard for diagnosis.ResultsIn total, 139 lesions were detected by CSMs and F-FDG PET/CT, of which there were 50 cutaneous and 89 extracutaneous-positive regions. F-FDG PET/CT detected 48 cutaneous and 88 extracutaneous regions. CSMs, however, detected only 34 cutaneous lesions and 61 extracutaneous lesions that were positive for malignancy (cutaneous comparison of PET/CT vs. CSMs, P<0.001; extracutaneous comparison of PET/CT vs. CSMs, P<0.05). Using F-FDG PET/CT, 8 (42%) patients were in stage I-II and 31 patients (58%) were in stage III-IV. F-FDG PET/CT staging was consistent with the final stage determination in 94.9% (37/39) of patients, whereas CSMs staging was correct in final stage determination in 74.4% (29/39) of patients (P=0.025).ConclusionOur study showed that F-FDG PET/CT scanning is a valuable modality for the detection of cutaneous and extracutaneous lesions of C-ENK/T-NT. F-FDG PET/CT may therefore influence future staging and treatment strategies.

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