• J Dermatolog Treat · Jan 2007

    Case Reports

    Cutaneous granulomatous reaction to injectable hyaluronic acid gel: another case.

    • Federico Bardazzi, Alberto Ruffato, Angela Antonucci, Riccardo Balestri, and Michela Tabanelli.
    • Department of Specialistic and Experimental Clinical Medicine, Division of Dermatology, University of Bologna, Italy.
    • J Dermatolog Treat. 2007 Jan 1; 18 (1): 59-62.

    AbstractWe report a case of a granulomatous reaction in the melolabial folds, occurring 10 days after treatment with Restylane. The patient, who had previously been treated with the same product in the last 2 years without any adverse effect, developed an unusual early fibrotic reaction that we hypothesized related to hypersensitivity after repeated use. The lesions slowly disappeared with topical steroid therapy. An improved knowledge of the modality of these uncommon adverse effects is necessary to assess the long-term safety and efficacy of this product.

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