• Reumatología clinica · Jul 2016

    Multicenter Study

    Sjögren's syndrome-associated interstitial lung disease: A multicenter study.

    • Delia Reina, Daniel Roig Vilaseca, Vicenç Torrente-Segarra, Dacia Cerdà, Ivan Castellví, Cèsar Díaz Torné, Mireia Moreno, Javier Narváez, Vera Ortiz, Rosana Blavia, Montserrat Martín-Baranera, and Hèctor Corominas.
    • Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain. Electronic address: deliareinasanz@gmail.com.
    • Reumatol Clin. 2016 Jul 1; 12 (4): 201-5.

    UnlabelledPrimary Sjögren syndrome (PSS) is a chronic inflammatory autoimmune disease. Interstitial lung disease (ILD) can be an extraglandular complication.ObjectiveTo evaluate the clinical characteristics of patients diagnosed with PSS with ILD.MethodsMulticentre cohort study with 25 patients diagnosed with PSS and ILD. Data of PSS, prognostic factors, pulmonary involvement variables, complementary tests that suggest a worse diagnosis and treatment given were collected. EULAR index was measured for Sjögren's syndrome.ResultsWe identified 25 patients. In 15/25 the diagnosis of ILD was done before the diagnosis of PSS. The histopathological patterns found were: 12 NSIP, 5 UIP, 4 OP, 2 LIP. PFRs showed restrictive pattern. The majority of the patients received glucocorticoid therapy, antimalarial or immunosuppressive treatment.ConclusionsPatients affected with PSS must be screened to catch a precocious diagnosis of ILD. The majority of the patients were diagnosed of ILD before being diagnosed of PSS. Multicenter cohorts are increasingly demanded and a multidisciplinary management is needed.Copyright © 2015 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

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