• Muscle & nerve · Oct 2008

    Case Reports

    Lewis-Sumner syndrome associated with infliximab therapy in rheumatoid arthritis.

    • Davyd R Hooper, Mark A Tarnopolsky, and Steven K Baker.
    • Department of Medicine, Neuromuscular Disease Clinic, Rm. 2H22, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5.
    • Muscle Nerve. 2008 Oct 1; 38 (4): 1318-25.

    AbstractWe report 2 cases of Lewis-Sumner syndrome (LSS) diagnosed in patients suffering from rheumatoid arthritis undergoing treatment with the antitumor necrosis factor alpha (TNF-alpha) monoclonal antibody infliximab. While experiencing clinical improvement in their arthritic symptoms, both patients experienced sensory deficits and weakness in multiple nerve distributions. They had electrodiagnostic evidence of motor conduction block and subsequent improvement with intravenous immunoglobulin (IVIg). We describe the details of the cases and review the literature on immune-mediated neuropathies associated with anti-TNF-alpha therapy.

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