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- Peter Hillmen, Jennifer R Brown, Barbara F Eichhorst, Nicole Lamanna, Susan M O'Brien, Lugui Qiu, Tommi Salmi, James Hilger, Kenneth Wu, Aileen Cohen, Jane Huang, and Constantine S Tam.
- Department of Haematology, Leeds Teaching Hospitals NHS Trust, Level 3 Bexley Wing, St James's University Hospital, Leeds LS9 7TF, UK.
- Future Oncol. 2020 Apr 1; 16 (10): 517-523.
AbstractTreatment standards for chronic lymphocytic leukemia (CLL) have been transformed with the advent of effective inhibitors of B-cell receptor signaling such as ibrutinib - a first-in-class inhibitor of BTK. Off-target kinase inhibitions by ibrutinib are thought to contribute to its adverse events. Zanubrutinib is a next-generation BTK inhibitor with minimal off-target effects, sustained BTK occupancy in peripheral blood mononuclear cells and lymph nodes from patients with B-cell malignancies and promising responses in patients with CLL. Described here is a head-to-head Phase III study comparing the efficacy and safety of zanubrutinib with those of ibrutinib in patients with CLL/small lymphocytic lymphoma in the relapsed/refractory setting.
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