• Dong-Pyo Jang, Jong-Min Lee, Eun Lee, Sangjin Park, Jae-Jin Kim, Kee Namkoong, Kang-Jun Yoon, In-Young Kim, and Sun I Kim.
• Department of Biomedical Engineering, Hanyang University, 17 Heangdang-dong, Sungdong-ku, Seoul 133-791, Korea.
• Magn Reson Med. 2005 Mar 1; 53 (3): 708-12.

AbstractThe goal of this study was to measure the interindividual reproducibility of glutamate quantification in 1.5-T (1)H MRS of human brains. To determine the effective echo time (TE) for glutamate quantification, spectra from a phantom and 12 participants were obtained with TE = 30, 35, 40, and 144 ms (repetition time (TR) = 2000 ms and volume of interest = 4 cm(3)). The average Cramer-Rao lower bounds for glutamate quantification using LCModel was lowest in two experiments when TE = 40 ms.Twenty-one subjects participated in experiments that measured interindividual reproducibility of glutamate quantification. Spectra were acquired with TR = 6000 ms and TE = 40 ms. Results showed that the coefficients of variance were 11.0 and 13.1% in the anterior cingulate cortex and insula, respectively. This suggests that glutamate can be reproducibly measured from 1.5-T (1)H MRS with long TR, effective TE, and the LCModel.(c) 2005 Wiley-Liss, Inc.

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