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- Arnab Ghosh, Pere Barba, and Miguel-Angel Perales.
- Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- Br. J. Haematol. 2020 Jan 1; 188 (1): 159-167.
AbstractImmunotherapy is distinct from traditional chemotherapy in that it acts on immune cells rather than cancer cells themselves. Monoclonal antibodies targeting immune checkpoints on T cells - CTLA-4 and PD-1 - and PD-L1 on the cells of immune microenvironment are now approved for clinical use in several solid tumors and hematological malignancies. This article provides a general overview of the use of checkpoint inhibitors in hematologic malignancies with a special focus in acute myeloid leukemia.© 2019 British Society for Haematology and John Wiley & Sons Ltd.
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