• Y Yu, W Xu, Z Xie, Q Huang, and S Li.
• Department of Gynaecology, Women's Hospital, School of Medicine, Zhejiang University, PR China.
• Eur. J. Obstet. Gynecol. Reprod. Biol. 2014 Sep 1; 180: 157-61.

ObjectiveTo characterize general attributes of women with heterotopic pregnancy (HP) in order to establish an optimal management regimen.Study DesignA retrospective analysis was conducted on 25 HPs recorded at the Women's Hospital of Zhejiang University between 2007 and 2011. Data on patients' symptoms, risk factors, diagnostic features, treatment and outcome were collected and analysed.ResultsAll patients had conceived via assisted reproductive technology (ART), 72% had a history of pelvic inflammatory disease and 68% of patients were symptomatic. Fifty-six percent of patients were diagnosed with HP via routine transvaginal ultrasound examination at approximately 6-7 weeks of gestation. Eighty percent of patients underwent surgical treatment (35% laparoscopic salpingectomy, 65% laparotomy), and 20% of patients underwent medical treatment with local injection of methotrexate (MTX) or MTX in combination with potassium chloride (KCl) into ectopic sites such as the cervix or interstitium. Eighty-eight percent of patients delivered live infants without congenital anomalies, and three patients (all of whom underwent surgical treatment) miscarried.ConclusionsRoutine transvaginal ultrasound examination at approximately 6-7 weeks of gestation could facilitate the diagnosis of HP, although repeat ultrasound is necessary to avoid misdiagnosis. Prompt diagnosis and correct treatment, including local injection of MTX or MTX in combination with KCl into various ectopic sites, led to favourable prognoses.Copyright © 2014. Published by Elsevier Ireland Ltd.

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