• Ke-Vin Chang, Tsai-Hsuan Hsu, Wei-Ting Wu, Kuo-Chin Huang, and Der-Sheng Han.
• Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taiwan.
• Age Ageing. 2017 Sep 1; 46 (5): 738-746.

Objectivesto explore whether sarcopenia is associated with depression.Designelectronic literature databases from PubMed, Scopus, Embase and Google Scholar were searched. A systematic review and meta-analysis of observational studies was conducted.Settingcommunity and outpatient clinic.Participantspeople with and without diagnoses of sarcopenia.Measurementsoutcome measures of depression.Resultsabout 15 articles were included, 5 of which were retrieved for narrative review. The crude odds ratios (ORs) between sarcopenia and depression were extracted from the remaining 10 studies, 6 of which also included adjusted ORs. Sarcopenia was associated with depression without adjusting covariates (crude OR, 1.640; 95% confidence interval (CI), 1.247-2.155). After adjusting for potential confounders such as age, gender, cognitive performance and physical activity, sarcopenia still demonstrated a significant positive association with depression (adjusted OR, 1.821; 95% CI, 1.160-2.859). A stratified analysis showed that the studies that used bioelectrical impedance analysis for measurement of body composition tended to have an elevated association between sarcopenia and depression compared with those that used dual-energy X-ray absorptiometry or equation estimation.Conclusionsarcopenia was independently associated with depression. The causal relationship between the two clinical conditions requires future validation with cohort studies.© The Author 2017. Published by Oxford University Press on behalf of the British Geriatrics Society.All rights reserved. For permissions, please email: journals.permissions@oup.com

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