• Eline K Vos, Geert J S Litjens, Thiele Kobus, Thomas Hambrock, Christina A Hulsbergen-van de Kaa, Jelle O Barentsz, Henkjan J Huisman, and Tom W J Scheenen.
• Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. e.vos@rad.umcn.nl
• Eur. Urol. 2013 Sep 1; 64 (3): 448-55.

BackgroundA challenge in the diagnosis of prostate cancer (PCa) is the accurate assessment of aggressiveness.ObjectiveTo validate the performance of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) of the prostate at 3 tesla (T) for the assessment of PCa aggressiveness, with prostatectomy specimens as the reference standard.Design, Settings, And ParticipantsA total of 45 patients with PCa scheduled for prostatectomy were included. This study was approved by the institutional review board; the need for informed consent was waived.Outcome Measurements And Statistical AnalysisSubjects underwent a clinical MRI protocol including DCE-MRI. Blinded to DCE-images, PCa was indicated on T2-weighted images based on histopathology results from prostatectomy specimens with the use of anatomical landmarks for the precise localization of the tumor. PCa was classified as low-, intermediate-, or high-grade, according to Gleason score. DCE-images were used as an overlay on T2-weighted images; mean and quartile values from semi-quantitative and pharmacokinetic model parameters were extracted per tumor region. Statistical analysis included Spearman's ρ, the Kruskal-Wallis test, and a receiver operating characteristics (ROC) analysis.Results And LimitationsSignificant differences were seen for the mean and 75th percentile (p75) values of wash-in (p = 0.024 and p = 0.017, respectively), mean wash-out (p = 0.044), and p75 of transfer constant (K(trans)) (p = 0.035), all between low-grade and high-grade PCa in the peripheral zone. ROC analysis revealed the best discriminating performance between low-grade versus intermediate-grade plus high-grade PCa in the peripheral zone for p75 of wash-in, K(trans), and rate constant (Kep) (area under the curve: 0.72). Due to a limited number of tumors in the transition zone, a definitive conclusion for this region of the prostate could not be drawn.ConclusionsQuantitative parameters (K(trans) and Kep) and semi-quantitative parameters (wash-in and wash-out) derived from DCE-MRI at 3 T have the potential to assess the aggressiveness of PCa in the peripheral zone. P75 of wash-in, K(trans), and Kep offer the best possibility to discriminate low-grade from intermediate-grade plus high-grade PCa.Copyright © 2013 European Association of Urology. Published by Elsevier B.V. All rights reserved.

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