• Am J Forensic Med Pathol · Mar 2010

    Case Reports

    Accidental intrathecal administration of vincristine.

    • Adriana D'Addario, Juan Galuppo, Carlos Navari, Marcelo Schultz, Nélida Cuello, Juan C Troncoso, and Miguel Angel Riudavets.
    • Forensic Office, Forensic Medical Corps, Buenos Aires, Argentina.
    • Am J Forensic Med Pathol. 2010 Mar 1; 31 (1): 83-4.

    AbstractWe describe a case of accidental intrathecal administration of vincristine in a 33-year-old man with clinical diagnosis of acute lymphocytic leukemia. The patient died 20 days after receiving the drug. Clinically, the patient developed acute ascending paralysis with motor and sensory dysfunctions, and respiratory failure. Neuropathological investigation revealed lesions in spinal cord, roots, and cerebellum characterized by rarefaction of the neuropil, axonal, and myelin degeneration, accompanied by macrophagic infiltration.

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