• Korean J Radiol · Jul 2012

    Influence of signal intensity non-uniformity on brain volumetry using an atlas-based method.

    • Masami Goto, Osamu Abe, Tosiaki Miyati, Hiroyuki Kabasawa, Hidemasa Takao, Naoto Hayashi, Tomomi Kurosu, Takeshi Iwatsubo, Fumio Yamashita, Hiroshi Matsuda, Harushi Mori, Akira Kunimatsu, Shigeki Aoki, Kenji Ino, Keiichi Yano, Kuni Ohtomo, and Japanese Alzheimer's Disease Neuroimaging Initiative.
    • Department of Radiological Technology, University of Tokyo Hospital, Tokyo 113-8655, Japan. car6_pa2_rw@yahoo.co.jp
    • Korean J Radiol. 2012 Jul 1; 13 (4): 391-402.

    ObjectiveMany studies have reported pre-processing effects for brain volumetry; however, no study has investigated whether non-parametric non-uniform intensity normalization (N3) correction processing results in reduced system dependency when using an atlas-based method. To address this shortcoming, the present study assessed whether N3 correction processing provides reduced system dependency in atlas-based volumetry.Materials And MethodsContiguous sagittal T1-weighted images of the brain were obtained from 21 healthy participants, by using five magnetic resonance protocols. After image preprocessing using the Statistical Parametric Mapping 5 software, we measured the structural volume of the segmented images with the WFU-PickAtlas software. We applied six different bias-correction levels (Regularization 10, Regularization 0.0001, Regularization 0, Regularization 10 with N3, Regularization 0.0001 with N3, and Regularization 0 with N3) to each set of images. The structural volume change ratio (%) was defined as the change ratio (%) = (100 × [measured volume - mean volume of five magnetic resonance protocols] / mean volume of five magnetic resonance protocols) for each bias-correction level.ResultsA low change ratio was synonymous with lower system dependency. The results showed that the images with the N3 correction had a lower change ratio compared with those without the N3 correction.ConclusionThe present study is the first atlas-based volumetry study to show that the precision of atlas-based volumetry improves when using N3-corrected images. Therefore, correction for signal intensity non-uniformity is strongly advised for multi-scanner or multi-site imaging trials.

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