• C Rossi, A Boss, T M Lindig, P Martirosian, G Steidle, W Maetzler, C D Claussen, U Klose, and F Schick.
• Sektion für Experimentelle Radiologie, Abteilung für Radiologische Diagnostik, Radiologische Universitätsklinik, Tübingen. cristina.rossi@med.uni-tuebingen.de
• Rofo. 2007 Mar 1; 179 (3): 219-24.

PurposeThe feasibility of highly resolved diffusion tensor imaging (DTI) of the human cervical spinal cord was tested on a clinical MR unit operating at 3.0 Tesla. DTI parametrical maps and signal-to-noise ratios (SNRs) were compared to results recorded at 1.5 Tesla.Materials And MethodsEight healthy volunteers and one patient participated in the study. A transverse oriented single-shot ECG-triggered echo-planar imaging (EPI) sequence with double spin-echo diffusion preparation was applied for highly resolved DTI of the spinal cord. The signal yield, fractional anisotropy (FA), and mean diffusivity (MD) were compared for both field strengths. The clinical applicability of the protocol was also tested in one patient with amyotrophic lateral sclerosis (ALS) at 3.0 T.ResultsA mean increase in SNR of 95.7 +/- 4.6 % was found at 3.0 Tesla compared to 1.5 Tesla. Improved quality of the DTI parametrical maps was observed at higher field strength (p < 0.02). Comparable FA and MD (reported in units of 10 (-3) mm (2)/s) values were computed in the dorsal white matter at both field strengths (1.5 T: FA = 0.75 +/- 0.08, MD = 0.84 +/- 0.12, 3.0 T: FA = 0.74 +/- 0.04, MD = 0.93 +/- 0.14). The DTI images exhibited diagnostic image quality in the patient. At the site of the diseased corticospinal tract, a decrease of 46.0 +/- 3.8 % in FA (0.40 +/- 0.03) and an increase of 50.3 +/- 5.6 % in MD (1.40 +/- 0.05) were found in the ALS patient.ConclusionThe 3.0 Tesla field strength provides higher image quality in DTI of the spinal cord compared to 1.5 T. The proposed DTI protocol seems adequate for the assessment of spinal cord diseases.

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