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- Ian D Pavord, Bart Hilvering, and Rahul Shrimanker.
- Department of Respiratory Medicine, University of Oxford, Old Road, Oxford, OX3 7LE, UK; Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, OX3 7FZ, UK. Electronic address: ian.pavord@ndm.ox.ac.uk.
- Immunol Allergy Clin North Am. 2016 Aug 1; 36 (3): 609-23.
AbstractAsthma is a heterogeneous disease that can be classified into different clinical endotypes, depending on the type of airway inflammation, clinical severity, and response to treatment. This article focuses on the eosinophilic endotype of asthma, which is defined by the central role that eosinophils play in the pathophysiology of the condition. It is characterized by persistently elevated sputum and/or blood eosinophils and by a significant response to treatments that suppress eosinophilia. Eosinophil activity in the airway may be more important than their numbers and this needs to be investigated. Transcriplomic or Metabolomic signatures may also be useful to identify this endotype.Copyright © 2016 Elsevier Inc. All rights reserved.
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