• Ebru Celik, Onder Celik, Ercan Yilmaz, Ilgin Turkcuoglu, Abdullah Karaer, Ugur Turhan, and Suleyman Aydin.
• Department of Obstetrics and Gynecology, Inonu University School of Medicine, Malatya, Turkey. ecelik05@googlemail.com
• Eur. J. Obstet. Gynecol. Reprod. Biol. 2013 Mar 1; 167 (1): 29-33.

ObjectivesTo evaluate maternal and cord serum concentrations of salusin-α and salusin-β in women with gestational diabetes mellitus (GDM) and with small-for-gestational age (SGA) fetuses.Study DesignPregnant women with GDM (n=25), women with SGA (n=20) and maternal age-matched normal healthy pregnant subjects (n=25) participated in the study. Maternal serum and cord blood salusin-α and salusin-β levels at the time of birth were measured using ELISA, and their relation with metabolic parameters was also assessed.ResultsMean concentrations of maternal and fetal serum salusin-α in the GDM and SGA groups were significantly lower than those of the controls (P<0.001, P<0.001, P<0.001 and P<0.001, respectively). Mean concentrations of maternal and cord blood salusin-β also decreased in both the GDM and the SGA groups in comparison to the control group (P<0.001, P<0.001, P<0.001 and P<0.001, respectively). The concentrations of maternal serum salusin-α and salusin-β were strongly positively correlated with the concentrations of cord blood salusin-α and salusin-β (R=0.92, P<0.001 and R=0.94, P<0.001, respectively).ConclusionsThe low levels of maternal serum salusin-α and salusin-β may have negative impact on metabolic disorders and vascular dysfunction.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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