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Gan To Kagaku Ryoho · Sep 2007
Case Reports[Successful desensitization using cisplatin after carboplatin-associated hypersensitivity reactions in 3 cases with recurrent ovarian carcinoma].
- Masayoshi Hosaka, Yasuhiko Ebina, Masashi Moriwaki, Yoko Hara, Naoto Araki, Yukiharu Todo, Mahito Takeda, Hidemichi Watari, and Noriaki Sakuragi.
- Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine.
- Gan To Kagaku Ryoho. 2007 Sep 1; 34 (9): 1505-8.
AbstractThe standard chemotherapy for ovarian carcinoma is paclitaxel and carboplatin concomitant therapy. This combination is so frequently administered that a carboplatin-associated hypersensitivity reaction may occur after long-term treatment. Recently, we experienced carboplatin-associated hypersensitivity reactions in three cases. They showed symptoms of tachycardia, chest tightness, and dyspnea. We report these cases that could be readministered platinum agent using the cisplatin desensitization method. This method was relatively safe and successful for patients with platinum-sensitive disease.
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