• José Antonio Rueda-Camino, Vanesa Sendín-Martín, María Dolores Joya-Seijo, María Angelina-García, Celia Zamarro-García, Francisco Javier Gimena-Rodríguez, and Raquel Barba-Martín.
• Internal Medicine Department, Multidisciplinary Venous Thromboembolism Unit, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, Spain. Electronic address: jose.rueda@hospitalreyjuancarlos.es.
• Med Clin (Barc). 2022 Mar 25; 158 (6): 265269265-269.

IntroductionD-dimer levels are elevated in COVID 19 and they correlate to the levels of other inflammatory markers such us ferritin, fibrinogen and C-reactive protein. It may be possible to correct D-dimer value in function of inflammatory markers, thus identifying patients at higher risk of venous thromboembolism (VTE). Our objectives are estimating a corrected value of plasma D-dimer as a linear function of ferritin, C-reactive protein and fibrinogen and stablishing a cut-off point of high probability of VTE.Patients And MethodsAge and sex matched case-control study of all patients diagnosed with COVID 19 and VTE between March and May 2020 in a tertiary hospital in Madrid (Spain). Using linear regression, the best predictive model will be estimated and residual D-dimer values will be obtained and analyzed using ROC curves to determine its discriminative performance.ResultsThirty-eight cases and seventy-six controls were included. There was 63.2% of men and mean age was 68.2. D-dimer was best predicted by a linear model including fibrinogen, ferritin and C-reactive protein. Using residual values, the optimal cutoff point was 2165ng/mL, with a sensitivity of 57.9% and specificity of 98.7%.ConclusionIt is possible to estimate a D-dimer corrected value in function of ferritin, C-reactive protein and fibrinogen. Using the observed and estimated value we can obtain a residual value that performs well as a screening method to detect patients who would benefit for further VTE diagnostic testing.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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