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Journal de chirurgie · Oct 2002
Review Comparative Study[At last, an effective therapy for non-differentiated GI sarcomas (gastro intestinal stromal tumor)].
- G Des Guetz, Ph De Mestier, and Jean-Yves Pierga.
- Département de médecine, Institut Curie, Paris, France.
- J Chir (Paris). 2002 Oct 1; 139 (5): 268-73.
AbstractGastrointestinal stromal tumors (GISTs) are non differentiated sarcoma of the gastrointestinal tract and have for a long time been confused with well differentiated tumors and classified as leiomyosarcoma. These tumors are characterized immunohistochemically by CD 117 staining. This marker represents the expression of c-kit which is a receptor for growth factor with enzymatic activity (tyrosine kinase). Recent studies have found that an inhibitor of specific tyrosine kinase is effective in the treatment of GIST with an estimated response rate of more than 60%. This new drug could significantly improve the prognosis of these aggressive chemoresistant tumors.
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