• Pediatr Int · Aug 2013

    Case Reports

    Anaphylactic reaction to polyethylene-glycol conjugated-asparaginase: premedication and desensitization may not be sufficient.

    • Umit M Sahiner, S Tolga Yavuz, Muge Gökce, Betul Buyuktiryaki, Ilhan Altan, Selin Aytac, Murat Tuncer, Ayfer Tuncer, and Cansin Sackesen.
    • Department of Pediatric Allergy and Asthma, Hacettepe University School of Medicine, Ankara, Turkey.
    • Pediatr Int. 2013 Aug 1; 55 (4): 531-3.

    AbstractIn hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene glycol conjugated asparaginase (PEG-ASP) is preferred. Anaphylaxis with PEG-ASP is rare. An 8-year-old girl and a 2.5-year-old boy, both diagnosed as having acute lymphoblastic leukemia, presented with native L-asparaginase hypersensitivity and substitution with PEG-ASP was preferred. They received a premedication (methylprednisolone, hydroxyzine and ranitidine) followed by desensitization with PEG-ASP infusion. Both patients developed anaphylaxis with peg-asparaginase. These are the first reported cases of anaphylactic reaction to PEG-ASP, despite the application of both premedication and desensitization. Anaphylaxis with PEG-ASP is very rare and premedication and desensitization protocols may not prevent these hypersensitive reactions. © 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.

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