• Yanbing Yu, Jie Chen, Zhichao Si, Guangyu Zhao, Shangchen Xu, Guangbin Wang, Feng Ding, Liming Luan, Lebin Wu, and Qi Pang.
• The Department of Neurosurgery, The China-Japan Friendship Hospital, East Yinghua Road, He Pingli, Chao Yang District, 100029, Beijing, People's Republic of China.
• Neurocrit Care. 2010 Feb 1; 12 (1): 117-23.

BackgroundTo investigate the hemodynamic response of the cerebral bridging veins to increased intracranial pressure (ICP) during normo- and hyperventilation.MethodsFlow velocity (FV(m)), diameter (D), and pulsatility index (PI) were measured and calculated in the cerebral bridging veins using Color Doppler Ultrasound in seven pigs, and cerebral blood flow (CBF) was measured using (133)Xe clearance in nine pigs, both during normo- and hyperventilation. ICP was increased stepwise from baseline (about 10 mmHg) to 20 and 30 mmHg by infusion of mock CSF into the cisterna magna.ResultsModerate elevations of ICP caused venous relative stasis as evidenced by a decrease in FV(m) and increase in diameter and PI, but no change of volume flow in the veins. CBF was stable indicating autoregulation at ICP of 20 and 30 mmHg. Parallel observations were made during normo- and hyperventilation, but at two different levels of CBF.ConclusionsThe cerebral bridging veins dilation and blood flow velocity decrease indicate the venous relative stasis in response to the elevated ICP. This response is proposed to be caused by an ICP-dependent increase in resistance to the outflow from the cerebral bridging veins.

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