• Saumil Ashvin Desai, Ruchi Nimish Nanavati, Bonny Bipin Jasani, and Nandkishor Kabra.
• Department of Neonatology, KEM Hospital, Seth G S Medical College, Mumbai, Maharashtra, India.
• Indian J Palliat Care. 2017 Jul 1; 23 (3): 287-292.

AimThis study aimed to compare Neonatal Pain, Agitation, and Sedation Scale (N-PASS) with Premature Infant Pain Profile (PIPP) for the assessment of acute prolonged pain in ventilated neonates.MethodsThis study was conducted in two phases. In phase 1 of the study, we assessed whether neonates on assisted ventilation experienced acute prolonged pain. In phase 2, the aim was to compare N-PASS with PIPP for the assessment of acute prolonged pain in neonates on assisted ventilation..DesignThis is a prospective observational study.Study Setting And DurationThis study was conducted at a tertiary care neonatal intensive care unit for 6 months.Inclusion CriteriaNeonates on assisted ventilation for >48 h were selected for this study.Exclusion CriteriaNeonates with lethal congenital anomalies and severe encephalopathy were excluded from the study. N-PASS and PIPP tools were used to assess acute prolonged pain in ventilated neonates. Taking PIPP as gold standard and N-PASS as a new test, the correlation coefficient was calculated. The sensitivity, specificity, positive predictive value, and negative predictive value were also computed. The time taken to administer the tools was also computed.ResultsThe average PIPP score for ventilated neonates was 8.33. The correlation coefficient of N-PASS when compared to PIPP was 0.62. The average time taken to apply the N-PASS scale was 4.42 min as compared to 8.20 min for PIPP scale. In term neonates, the sensitivity, specificity, positive predictive value, and negative predictive value of N-PASS were 75%, 100%, 100%, and 60%, respectively. The corresponding values in preterm neonates were lesser.ConclusionsThe study proves that neonates on assisted ventilation experience acute prolonged pain. N-PASS is clinically reliable and valid to assess acute prolonged pain in ventilated term neonates. The N-PASS is quicker than PIPP in assessing acute prolonged pain in ventilated neonates.Future DirectionsThe modified N-PASS tool (including the gestational age) should be developed.

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